1. Metformin Hcl Tablets

Development and evaluation of metformin hydrochloride 500mg. Evaluation of content uniformity test Twenty tablets of each formulation were weighed. Dissolution test of all the hydrophilic. Glucophage ® is the patent drug of Metformin Hydrochloride. Branded drugs are expensive than locally marketed drug. Substitution of drugs is very essential for the people of under developing country. Three different brands of Metformin Hydrochloride tablets which are available in Bangladesh like Glucomet, Daomina and Met were.

WARNING: LACTIC ACIDOSISPostmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain.

Metformin Hcl Tablets

Metformin-associated lactic acidosis was characterized by elevated blood lactate levels (5 mmol/Liter), anion gap acidosis (without evidence of ketonuria or ketonemia), an increased lactate/pyruvate ratio; and metformin plasma levels generally 5 mcg/mL see.Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (e.g. Carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, and hepatic impairment.Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are provided see,.If metformin-associated lactic acidosis is suspected, immediately discontinue metformin hydrochloride extended-release tablets and institute general supportive measures in a hospital setting. Prompt hemodialysis is recommended see. 1 INDICATIONS AND USAGEMetformin hydrochloride extended-release tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Nominal and verbal style.

Hello,I am Hyung-Taek Lim working for pharmaceuticals in Korea.We have glimepiride /metformin HCl immediate and slow-release combination tablets.I have found several academic analytical papers regarding Simultaneous determination of metformin and glimepride in pharmaceutical dosage by HPLC but there is no clear about dissolution medium for simultaneous release of glimepiride /metformin HCl combination tablets.if someone who had or have been working with this Please let me know.Thanks for your help.Sincerely. A quick check of the USP does not show a monograph for a combination product such as this, but there is valuable information there: dissolution of metformin HCl extended release tablets is done in pH 6.8 buffer (App 2 at 100 rpm or App 1 at 100 rpm, depending on potency). Dissolution for glimepiride tablets uses pH 7.8 buffer with App 2 at 75 rpm.If the metformin HCl conditions are appropriate for your product, then I would check solubility of glimepiride at pH 6.8, and try performing the dissolution under the conditions specified for the metformin product. If it works well, you are on your way to developing an appropriate method.Good luck,Greg.